Brock Purdy’s turf-toe injury sidelines the 49ers QB for up to five weeks, thrusting Mac Jones into Sunday’s matchup with New Orleans. Fantasy managers should scan the QB streamer list, with Daniel Jones, Trevor Lawrence, and even Aaron Rodgers cited as viable options in tougher spots.

Week 1’s injury avalanche continued with Austin Ekeler’s season-ending Achilles and George Kittle’s hamstring. Add in Xavier Worthy’s shoulder and Brock Bowers’s knee, and the waiver wire becomes a chessboard. Watch for sleepers like Harold Fannin Jr. and Emeka Egbuka to emerge for deeper leagues.

Chris Godwin remains out for Week 2 as he recovers from a dislocated ankle that required surgery last season. Limited practice signals progress, but the Buccaneers plan to ease him back, with Week 5 penciled as a target debut. Emeka Egbuka has emerged, giving Tampa Bay a viable rookie option alongside a reshaped offense led by Baker Mayfield and new OC Josh Grizzard. Godwin's return will likely restore WR2 upside, but the immediate impact is muted until he’s back in game shape.

For fantasy managers, the absence in Week 2 reduces Week 2 risk but shifts targets toward Egbuka and Mayfield’s rhythm. Once healthy, Godwin should regain a prominent role, though his ceiling will depend on how quickly he builds rapport with the new system and on-field chemistry with Mayfield.